Contract Services

Nature of the Opportunity

• Preclinical studies to validate new drug targets
• Evaluation of drug delivery technologies
• Target discovery using innovative approaches and high throughput technologies.

Allergenix has extensive technical capabilities and capacity in the following areas:

• Ethical animal management facilities
• Screening for allergen-specific IgE levels
• Bronchoscopic techniques allowing segmental lung-delivery of allergens/drugs and comparison within the same sheep
• Drug and allergen delivery by aerosol
• Extensive experience with histological and immunological techniques
  • Inflated lung fixation to preserve morphology
  • Frozen sections and immunohistology
  • Detection of mucosal and systemic Ab isotypes
  • Morphometric analysis
  • Measurement of cytokines
  • Flowcytometry of BAL and peripheral blood
• Lung mechanics analysis in awake animals
  • Lung compliance
  • Airway resistance
  • Tidal volumes and breathing rates
  • Airway hyperreactivity