Key Publications
Pulmonary Fibrosis Foundation (PFF) 2023 Summit, 9-11 November 2023, Orlando FL, USA. Poster presentation: Biodistribution of inhaled AD-214 in a sheep model of lung fibrosis – a proof of concept study
American Thoracic Society (ATS) International Conference, 19-24 May, 2023, Washington DC, USA. Poster presentations: (1) Features of a clinically relevant large animal model of Chronic Obstructive Pulmonary Disease (COPD); (2) Inhibition of poly (ADP-Ribose) polymerase attenuates bleomycin-induced pulmonary fibrosis in a sheep model
American Thoracic Society (ATS) Respiratory Innovation Summit (RIS), 19-20 May, 2023, Washington DC, USA. Poster presentation: Preclinical models for pulmonary disease and drug delivery
Lorne Infection & Immunity Conference, 15-17 February, 2023, Lorne, VIC, Australia. Poster presentation: Features of a novel sheep model of ALI/ARDS induced by pulmonary instillation of live Streptococcus pneumoniae
Edirisinghe HS, Rajapaksa AE, Royce SG, Sourial M, Bischof RJ, Anderson J, Sarila G, Nguyen CD, Mulholland K, Do LAH & Licciardi PV (2023). Aerosol delivery of palivizumab in a neonatal lamb model of Respiratory Syncytial Virus Infection. Viruses 15:2276; Download – Sheep RSV model: inhaled palivizumab
Weiss A, Bischof RJ, Landersdorfer CB, Nguyen TH, Davies A, Ibrahim J, Wynne P, Wright P, Ditzinger G, Montgomery AB, Meeusen E, McIntosh MP & Sommer MO (2023). Single-dose pharmacokinetics and lung function of nebulized niclosamide ethanolamine in sheep. Pharm Res 40:1915; Download – PK studies: inhaled niclosamide
Ibrahim JP, Haque S, Bischof RJ, Whittaker AK, Whittaker MR & Kaminskas LM (2022). Liposomes are poorly absorbed via lung lymph after inhaled administration in sheep. Front Pharmacol 13:880448. doi: 10.3389/fphar.2022.880448; Download – PK studies: inhaled liposomes
Poster presentation at RDD2020: Bischof RJ, Davies A, Meeusen E, Piedrafita D (2020). Preclinical Sheep Models for Pulmonary Disease and Drug Deposition Studies. Respiratory Drug Delivery 2020, 2:279.
Poster presentation at RDD2020: Rosiere R, Bischof RJ, Chraibi S, Gérard P, Hennia I, Meeusen E, Amighi K, Wauthoz N (2020). Pharmacokinetic and Preliminary Toxicity Investigation of an Innovative Controlled-Release Cisplatin Dry Powder Inhalation Formulation in Sheep. Respiratory Drug Delivery 2020, 3:521.
Poster presentation at the American Thoracic Society, ATS International Conference, 2019: Dallas, USA, 17-22 May, 2019. Surber M, Kaminskas L, Landersdorfer C, Bischof R, Beck S, Pham S, Jain A, Halvarsson A, Hug M & Montgomery A (2019). Pharmacokinetics and Safety of Pirfenidone Following Inhaled Delivery to Sheep: A Viable Approach to Treating Idiopathic Pulmonary Fibrosis.
Kaminskas LM, Landersdorfer CB, Bischof RJ, Leong N, Ibrahim J, Davies AN, Pham S, Beck S, Montgomery AB & Surber MW (2019). Aerosol pirfenidone pharmacokinetics after inhaled delivery in sheep: a viable approach to treating Idiopathic Pulmonary Fibrosis. Pharm Res 37:3; Download – PK studies: inhaled pirfenidone
Oral presentation at the 17th Fraunhofer Seminar “Models of Lung Disease” in Hannover, Germany from 18-19 January, 2018: Download presentation – Sheep models for testing respiratory delivery technologies and drug formulations
Ryan GM, Bischof RJ, Enkhbaatar P, McLeod VM, Chan LJ, Jones SA, Owen DJ, Porter CJH & Kaminskas LM (2016). A Comparison of the pharmacokinetics and pulmonary lymphatic exposure of a generation 4 PEGylated dendrimer following intravenous and aerosol administration to rats and sheep. Pharm Res 33: 510; Download – PK studies: pulmonary drug delivery
Liravi B, Piedrafita D, Nguyen G & Bischof RJ (2015). Dynamics of IL-4 and IL-13 expression in the airways of sheep following allergen challenge. BMC Pulmonary Medicine 15:101; Download – Sheep Allergic Asthma Model: TH2 cytokines
Nebulized perflubron and carbon dioxide rapidly dilate constricted airways in an ovine model of allergic asthma (2014). Download – RESP RES, 2014 (see also video link: airway bronchodilator – rapid bronchodilation effect observed following test delivery of a proprietary agent)
Rajapaksa A, Ho J, Qi A, Bischof RJ, Nguyen T-H, Tate M, Piedrafita D, McIntosh M, Yeo L, Meeusen EN, Coppel R, & Friend J (2014). Effective aerosolized delivery of a plasmid DNA vaccine using a novel surface acoustic wave nebulizer. Respiratory Research 15: 60; Download – Airway DNA vaccine
Organ L, et al., (2014). A novel segmental challenge model for bleomycin-induced pulmonary fibrosis in sheep. Exp Lung Research: doi:10.3109/01902148.2014.985806; Download – Pulmonary Fibrosis
KCa3.1 Channel-Blockade Attenuates Airway Pathophysiology in a Sheep Model of Chronic Asthma (2013). Download – PLoS ONE, 2013b
Pulmonary Delivery of an Ultra-Fine Oxytocin Dry Powder Formulation: Potential for Treatment of Postpartum Haemorrhage in Developing Countries (2013). Download – PLoS ONE, 2013a (see also video link: dry-powder delivery – demonstration of pulmonary delivery of a dry-powder formulation into sheep airways; this was performed using a Penn-Century dry powder insufflator and fibre-optic endoscope positioned at the distal end of the trachea near the first bronchial bifurcation)
Meeusen ENT, Snibson KJ, Hirst SJ, & Bischof RJ (2010). Sheep as a model for the study and treatment of human asthma and other respiratory diseases. Drug Discovery Today: Disease Models 6: 101-106; Download – SheepModels
Snibson KJ, Bischof, RJ, Slocombe, RF & Meeusen EN (2005). Airway remodeling and inflammation in sheep lungs after chronic airway challenge with house dust mite. Clinical and Experimental Allergy 35: 146-152; Downloads – Sheep Chronic Asthma Model; Editorial-Models&Supermodels
Bischof RJ, Snibson K & Meeusen ENT (2003). Induction of allergic inflammation in the lungs of sensitized sheep after local challenge with house dust mite. Clinical and Experimental Allergy 33: 367-375; Downloads – Sheep Allergic Asthma Model; Editorial-Comparative&Complimentary
